Abnormal reactions to environmental stress in elderly persons with anxiety disorders: Evidence from a population study of diurnal cortisol changes.
Identifieur interne : 000265 ( France/Analysis ); précédent : 000264; suivant : 000266Abnormal reactions to environmental stress in elderly persons with anxiety disorders: Evidence from a population study of diurnal cortisol changes.
Auteurs : Isabelle Chaudieu [France] ; Isabelle Beluche [France] ; Joanna Norton [France] ; Jean-Philippe Boulenger [France] ; Karen Ritchie [France] ; Marie-Laure Ancelin [France]Source :
- Journal of Affective Disorders [ 0165-0327 ] ; 2008-03.
English descriptors
- mix :
Abstract
BACKGROUND: Cortisol secretion in elderly persons with anxiety disorders exposed to common stressful situations has not been evaluated. METHODS: Salivary-free cortisol levels were evaluated at 8, 15, and 22 h, in 201 elderly subjects during stressful and non-stressful days. Psychiatric symptomatology was assessed by a standardized psychiatric examination (MINI). RESULTS: Elderly subjects without psychiatric disorder showed a sustained increase in cortisol secretion several hours after the exposure to a stressful situation. In comparison, subjects with anxiety disorders showed a greater increase in cortisol secretion in the stressful situation, with lowered recuperation capacity. This effect was dose-dependent as a function of anxiety co-morbidity. Persons reporting lifetime major trauma with intrusions exhibited lowered continuous basal cortisol associated with efficient recuperation capacity. Independently of psychopathology, women appeared more reactive to stressful environmental conditions. LIMITATIONS: Exclusion of institutionalized persons and benzodiazepine users may have led to sampling of less severe anxiety symptoms. CONCLUSIONS: Dysregulation of the hypothalamic-pituitary-adrenal axis was observed in elderly persons with anxiety disorders experiencing environmental stress. A common pattern of up-regulated diurnal cortisol secretion was observed in anxious subjects with lifetime and current anxiety disorder irrespective of sub-type (generalized anxiety, phobias) suggesting a stable trait and a common "core" across disorders. Elderly persons who had experienced trauma with subsequent intrusions showed a distinct pattern with down-regulated activity.
Url:
DOI: 10.1016/j.jad.2007.07.025
Affiliations:
- France
- Languedoc-Roussillon, Occitanie (région administrative)
- Montpellier
- PRES Sud de France, Université Montpellier 1
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Hal:inserm-00194081Le document en format XML
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CS 19044 - 34967 Montpellier cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-montp1.fr/</ref> </desc> </org></tutelle><tutelle name="U1061" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno> <orgName>Université de Montpellier</orgName> <orgName type="acronym">UM</orgName> <desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.umontpellier.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName><orgName type="university">Université Montpellier 1</orgName><orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName></affiliation></author><author><name sortKey="Norton, Joanna" sort="Norton, Joanna" uniqKey="Norton J" first="Joanna" last="Norton">Joanna Norton</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139836" status="VALID"> <idno type="RNSR">201120699F</idno> <orgName>Neuropsychiatrie : recherche épidémiologique et clinique</orgName> <desc> <address> <addrLine>Hôpital La Colombière 39 AV Charles Flahault BP 34493 -Pav 42 Calixte Cavalier 34093 CEDEX 5 Montpellier</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-42570" type="direct"></relation> <relation name="U1061" active="#struct-303623" type="direct"></relation> <relation active="#struct-410122" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName> <orgName type="acronym">UM1</orgName> <date type="end">2014-12-31</date> <desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-montp1.fr/</ref> </desc> </org></tutelle><tutelle name="U1061" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno> <orgName>Université de Montpellier</orgName> <orgName type="acronym">UM</orgName> <desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.umontpellier.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName><orgName type="university">Université Montpellier 1</orgName><orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName></affiliation></author><author><name sortKey="Boulenger, Jean Philippe" sort="Boulenger, Jean Philippe" uniqKey="Boulenger J" first="Jean-Philippe" last="Boulenger">Jean-Philippe Boulenger</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139836" status="VALID"> <idno type="RNSR">201120699F</idno> <orgName>Neuropsychiatrie : recherche épidémiologique et clinique</orgName> <desc> <address> <addrLine>Hôpital La Colombière 39 AV Charles Flahault BP 34493 -Pav 42 Calixte Cavalier 34093 CEDEX 5 Montpellier</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-42570" type="direct"></relation> <relation name="U1061" active="#struct-303623" type="direct"></relation> <relation active="#struct-410122" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName> <orgName type="acronym">UM1</orgName> <date type="end">2014-12-31</date> <desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-montp1.fr/</ref> </desc> </org></tutelle><tutelle name="U1061" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno> <orgName>Université de Montpellier</orgName> <orgName type="acronym">UM</orgName> <desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.umontpellier.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName><orgName type="university">Université Montpellier 1</orgName><orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139836" status="VALID"> <idno type="RNSR">201120699F</idno> <orgName>Neuropsychiatrie : recherche épidémiologique et clinique</orgName> <desc> <address> <addrLine>Hôpital La Colombière 39 AV Charles Flahault BP 34493 -Pav 42 Calixte Cavalier 34093 CEDEX 5 Montpellier</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-42570" type="direct"></relation> <relation name="U1061" active="#struct-303623" type="direct"></relation> <relation active="#struct-410122" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName> <orgName type="acronym">UM1</orgName> <date type="end">2014-12-31</date> <desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-montp1.fr/</ref> </desc> </org></tutelle><tutelle name="U1061" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno> <orgName>Université de Montpellier</orgName> <orgName type="acronym">UM</orgName> <desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.umontpellier.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName><orgName type="university">Université Montpellier 1</orgName><orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName></affiliation></author><author><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139836" status="VALID"> <idno type="RNSR">201120699F</idno> <orgName>Neuropsychiatrie : recherche épidémiologique et clinique</orgName> <desc> <address> <addrLine>Hôpital La Colombière 39 AV Charles Flahault BP 34493 -Pav 42 Calixte Cavalier 34093 CEDEX 5 Montpellier</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-42570" type="direct"></relation> <relation name="U1061" active="#struct-303623" type="direct"></relation> <relation active="#struct-410122" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName> <orgName type="acronym">UM1</orgName> <date type="end">2014-12-31</date> <desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-montp1.fr/</ref> </desc> </org></tutelle><tutelle name="U1061" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno> <orgName>Université de Montpellier</orgName> <orgName type="acronym">UM</orgName> <desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.umontpellier.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName><orgName type="university">Université Montpellier 1</orgName><orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName></affiliation></author></analytic><idno type="DOI">10.1016/j.jad.2007.07.025</idno><series><title level="j">Journal of Affective Disorders</title><idno type="ISSN">0165-0327</idno><imprint><date type="datePub">2008-03</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>HPA axis</term><term>anxiety disorders</term><term>elderly</term><term>stress</term><term>traumatism</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>BACKGROUND: Cortisol secretion in elderly persons with anxiety disorders exposed to common stressful situations has not been evaluated. METHODS: Salivary-free cortisol levels were evaluated at 8, 15, and 22 h, in 201 elderly subjects during stressful and non-stressful days. Psychiatric symptomatology was assessed by a standardized psychiatric examination (MINI). RESULTS: Elderly subjects without psychiatric disorder showed a sustained increase in cortisol secretion several hours after the exposure to a stressful situation. In comparison, subjects with anxiety disorders showed a greater increase in cortisol secretion in the stressful situation, with lowered recuperation capacity. This effect was dose-dependent as a function of anxiety co-morbidity. Persons reporting lifetime major trauma with intrusions exhibited lowered continuous basal cortisol associated with efficient recuperation capacity. Independently of psychopathology, women appeared more reactive to stressful environmental conditions. LIMITATIONS: Exclusion of institutionalized persons and benzodiazepine users may have led to sampling of less severe anxiety symptoms. CONCLUSIONS: Dysregulation of the hypothalamic-pituitary-adrenal axis was observed in elderly persons with anxiety disorders experiencing environmental stress. A common pattern of up-regulated diurnal cortisol secretion was observed in anxious subjects with lifetime and current anxiety disorder irrespective of sub-type (generalized anxiety, phobias) suggesting a stable trait and a common "core" across disorders. Elderly persons who had experienced trauma with subsequent intrusions showed a distinct pattern with down-regulated activity.</p> </div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li></region><settlement><li>Montpellier</li></settlement><orgName><li>PRES Sud de France</li><li>Université Montpellier 1</li></orgName></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Chaudieu, Isabelle" sort="Chaudieu, Isabelle" uniqKey="Chaudieu I" first="Isabelle" last="Chaudieu">Isabelle Chaudieu</name></region><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><name sortKey="Beluche, Isabelle" sort="Beluche, Isabelle" uniqKey="Beluche I" first="Isabelle" last="Beluche">Isabelle Beluche</name><name sortKey="Boulenger, Jean Philippe" sort="Boulenger, Jean Philippe" uniqKey="Boulenger J" first="Jean-Philippe" last="Boulenger">Jean-Philippe Boulenger</name><name sortKey="Norton, Joanna" sort="Norton, Joanna" uniqKey="Norton J" first="Joanna" last="Norton">Joanna Norton</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Abnormal reactions to environmental stress in elderly persons with anxiety disorders: Evidence from a population study of diurnal cortisol changes.
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